| 货号 | BAF1639 |
| 别名 | CLEC5A; CLECSF5; CLECSF5carbohydrate-recognition domain) lectin, superfamilymember 5; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL-1MGC138304; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1 | 全称 | Myeloid DAP12-associating Lectin |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects mouse MDL‑1/CLEC5A in Western blots. In Western blots, approximately 5% cross-reactivity with recombinant human MDL-1 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 23601 (Human); 23845 (Mouse) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse MDL‑1/CLEC5A Tyr26-Lys190 Accession # AAI04365 |
| 生物活性 | Mouse |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | MDL-1 is anapproximately 40 kDa transmembrane glycoprotein belonging to the C-type lectinsuperfamily (CLEC5A). MDL-1 is expressed on immature myeloid cells, monocytes,macrophages, dendritic cells, neutrophils, NK cells, and osteocytes. Itcontains a charged lysine in the transmembrane region that enables it toassociate with DAP12 and deliver an activating signal. MDL-1 mediates inflammatory responses duringautoimmune arthritis and upon binding to Dengue and Japanese encephalitisviruses. The extracellular domain (ECD) of MDL-1 contains a juxtamembrane stalkregion and one C-type lectin domain. Within the ECD, mouse and human MDL-1share 67% amino acid sequence identity. In mouse, alternative splicinggenerates a short isoform with a 25 aa deletion in the stalk region. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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