| 货号 | BAF5725 |
| 别名 | CDSN; corneodesmosin; D6S586E; differentiated keratinocyte S protein; HTSS; S protein; S |
| 反应种属 | Human |
| 应用 | Western Blot |
| 目标/特异性 | Detects human Corneodesmosin in Western blots. |
| 使用方法 | Western Blot |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 1041 (Human); 386463 (Mouse) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human Corneodesmosin Lys33-Pro529 (Ser153 del) Accession # NP_001255 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Corneodesmosin (CDSN) is a highly polymorphic glycoprotein that is secreted by differentiated keratinocytes and by inner root sheath cells of hair follicles. Corneodesmosin forms oligomers and associates homophilically to strengthen the adhesion between corneocytes. Sequential proteolysis of Corneodesmosin diminishes its ability to mediate adhesion, and this is a prerequisite for normal desquamation of the skin. Defects in the synthesis or proteolysis of Corneodesmosin are associated with the development of psoriasis and hypotrichosis of the scalp. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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