货号 | BAF5378 |
别名 | anterior pharynx-defective 2; APH2; ATAG1874; KIAA0253APH2; NCSTN; nicastrin |
反应种属 | Human |
应用 | Western Blot(0.1 µg/mL) |
目标/特异性 | Detects human Nicastrin Isoform 1 in Western blots. |
使用方法 | Western Blot: 0.1 µg/mL |
来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
产品组分 |
供应商 | R&D Systems |
Entrez Gene IDs | 23385 (Human); 59287 (Mouse); 289231 (Rat) |
纯化方式 | Antigen Affinity-purified |
免疫原 | Chinese hamster ovary cell line CHO-derived recombinant human Nicastrin Isoform 1 Asn34-Glu669 Accession # Q92542 |
生物活性 | Human |
标记 | Biotin |
溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
背景 | Nicastrin (NCT) is a 150 - 160 kDa member of the nicastrin family of proteins. It is a component of the aspartyl protease γ-secretase complex and serves to stabilize and direct γ-secretase components to proper positions in the plasma membrane. The γ-secretase complex mediates the cleavage of intramembrane proteins such as notch-1 and APP. Mature human nicastrin is a 676 amino acid type I transmembrane glycoprotein. It contains a 636 aa extracellular domain (aa 34 - 669) that shows a 58 aa sequence (aa 312 - 369) which interacts with γ-secretase substrates. There are multiple splice variants of nicastrin. Over aa 34 - 669, human nicastrin shares 90% aa identity with mouse nicastrin. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
参考文献 |
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