| 货号 | BAF4907 |
| 别名 | D3S3195; EC 2.7.10; EC 2.7.10.1; hydroxyaryl-protein kinase; JTK5; JTK5A protein tyrosine kinase; JTK5A; RYK receptor-like tyrosine kinase; RYK1; tyrosine-protein kinase RYK | 全称 | Receptor Type Tyrosine Protein Kinase RYK |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Ryk in Western blots. In Western blots, approximately 40% cross-reactivity with recombinant mouse Ryk is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 6259 (Human); 20187 (Mouse); 140585 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human Ryk Ala47-Thr224 Accession # NP_002949 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Ryk (Related to tyrosine (Y) kinase; also VIK and MRK) is a member of the tyrosine protein kinase family. It is a type I transmembrane glycoprotein that binds Wnt and forms a Wnt receptor complex with Frizzled. In this capacity, Ryk serves as a link between Wnt and Dishevelled. Human Ryk is 604 amino acids (aa) in length. It contains a 25 aa signal sequence and a 199 aa extracellular region (aa 26 - 224) that shows one WIF-1-like domain (aa 63 - 191). The cytoplasmic region of Ryk possesses a nonfunctional Ser/Thr protein kinase domain (aa 327 - 600). One isoform exists that shows a 31 aa substitution between aa 18 - 46. Over aa 47 - 224, human Ryk is 94% aa identical to mouse Ryk. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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