概述| 货号 | BAF4888 |
| 别名 | CD301 antigen; CD301; CD301C-type lectin domain family 10 member A; CLECSF13; CLECSF14; CLECSF14macrophage C-type lectin; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 14 (macrophage-derived); C-type lectin domain family 10, member A; C-type lectin superfamily member 14; HML2; HMLC-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 13 (macrophage-derived); macrophage lectin 2 (calcium dependent); Macrophage lectin 2; MGL |
全称 | Macrophage Galactose N-Acetyl-Galactosamine Specific Lectin 1 | | 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL)
|
| 目标/特异性 | Detects human CLEC10A/CD301 in Western blots. In Western blots, less than 2% cross-reactivity with recombinant human (rh) CLEC1, rhCLEC2, and rhCLEC3B is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL
|
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 10462 (Human) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human CLEC10A/CD301 (Catalog # 4888-CL)
Gln61-His316
Accession # Q8IUN9 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | CLEC10A, also known as MGL, CD301, DC-ASGPR, and HML, is a transmembrane C-type lectin family that is expressed on immature myleloid dendritic cells, Langerhans cells, and alternatively activated (tolerogenic) macrophages. It is upregulated on pro-inflammatory monocytes in obesity and promotes their trafficking to adipose tissue. CLEC10A selectively binds and internalizes terminal nonsialylated GalNAc moieties on O-linked carbohydrates including the Tn carcinoma antigen and carbohydrates on some CD45 isoforms. It also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - C-type Lectin Family
- Macrophage Activation Markers
- Mouse Tissue-Resident Macrophage Markers
|
