货号 | BAF4359 |
别名 | EC 3.5.1.98; HD8; HDAC8; HDACL1; histone deacetylase 8; histone deacetylase-like 1; RPD3 |
反应种属 | Human/Mouse |
应用 | Western Blot(0.1 µg/mL) |
目标/特异性 | Detects human Histone Deacetylase 8/HDAC8 in Western blots. |
使用方法 | Western Blot: 0.1 µg/mL |
来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
产品组分 |
供应商 | R&D Systems |
Entrez Gene IDs | 55869 (Human); 70315 (Mouse); 363481 (Rat) |
纯化方式 | Antigen Affinity-purified |
免疫原 | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Histone Deacetylase 8/HDAC8 isoform 1 Met1-Val377 Accession # ACT64512 |
生物活性 | Human, Mouse |
标记 | Biotin |
溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
背景 | Human Histone Deacetylase 8 (HDAC8) is a member of the class I histone Deacetylases (HDACs). Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor trichostatin A. Sirtuin 2, is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging (3 - 4). The enzymatic activity of class III HDACs is nicotinamide adenine dinucleotide (NAD) dependent and insensitive to HDAC inhibitor trichostatin A |
运输条件 | Blue Ice |
存放说明 | -20℃ |
参考文献 |
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