| 货号 | BAF4097 |
| 别名 | AEPLC; Asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; beta secretase 2; beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAPBAE2; EC 3.4.23; EC 3.4.23.45; memapsin-1; Membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1 | 全称 | beta-site Ayloid Precursor Protein Cleaving Enzyme 2 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human BACE‑2 Ectodomain in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) BACE-1, rhCathepsin D, and rhCathepsin E is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 25825 (Human); 56175 (Mouse); 288227 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human BACE-2 Gly63-Pro466 Accession # Q9Y5Z0.1 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Both BACE-1 and BACE-2 are membrane-bound aspartic proteases of the pepsin family. BACE-1 is a potential target for treatment of Alzheimers disease because it is the principle b-secretase responsible for cleavage of amyloid precursor protein (APP). BACE-2 differs from BACE-1 in several aspects including pro-enzyme activation, substrate binding sites, transcriptional regulation, and function in A beta peptide production. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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