| 货号 | BAF4070 |
| 别名 | protein SOX-15; SOX20; SOX20Protein SOX-20; SOX26; SOX26SOX12; SOX27; SOX27Protein SOX-12; SRY (sex determining region Y)-box 15; SRY (sex determining region Y)-box 20 | 全称 | Transcription Factor SOX15 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human SOX15 in Western blots. In Western blots, less than 5% cross-reactivity with recombinant human (rh) SOX1, 5, 6, 7, 9, 13, and 17 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 6665 (Human); 20670 (Mouse); 363632 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human SOX15 Met1-Leu233 Accession # O60248 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Members of the large SOX family of transcription factors are widely conserved and at least 20 are found in mammals. Structurally SOX proteins exhibit a high mobility group (HMG) motif that binds the DNA minor groove. SOX family members are often found in multiprotein complexes that regulate their ability to affect transcription. SOX proteins play important roles in early development and are often used as markers to assess the differentiation of specific cell lineages. SOX15 (also known as SOX20) is a nuclear, 25 kDa transcriptional repressor that belongs to group G of the SOX gene family. Human SOX15 is 233 amino acids (aa) in length and contains a 63 aa DNA-binding HMG-box (amino acids 48 - 110). Although the C-terminus (aa 126 - 233) does not bind DNA, it is required for SOX15 repressive activity. It may accomplish this by interacting with β-catenin. SOX15 is expressed in myoblasts and regulates skeletal muscle regeneration and differentiation. Human SOX15 shares 75% aa sequence identity with mouse SOX15. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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