货号 | BAF3867 |
别名 | FGF-22; fibroblast growth factor 22 | 全称 | Fibroblast Growth Factor 22 |
反应种属 | Human |
应用 | Western Blot(0.1 µg/mL) |
目标/特异性 | Detects human FGF-22 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) FGF acidic, rhFGF-7, and rhFGF-10 is observed. |
使用方法 | Western Blot: 0.1 µg/mL |
来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
产品组分 |
供应商 | R&D Systems |
Entrez Gene IDs | 27006 (Human); 67112 (Mouse); 170579 (Rat) |
纯化方式 | Antigen Affinity-purified |
免疫原 | E. coli-derived recombinant human FGF-22 Thr23-Ser170 Accession # Q9HCT0 |
生物活性 | Human |
标记 | Biotin |
溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
背景 | Fibroblast growth factor-22 (FGF-22) is a 23 kDa, nonglycosylated member of the FGF-7 subfamily, FGF family of heparin-binding growth factors. The human FGF-22 precursor is 170 amino acids (aa) in length, and contains a 22 aa signal sequence with a 148 aa mature region. FGF-22 is synthesized by at least three cell types; keratinocytes, neurons, and skeletal muscle myotubes. In neurons and myotubes, FGF-22 is presumed to function as an organizer of the presynaptic apparatus. Expressed by postsynaptic (or target) cells, FGF-22 is believed to bind to FGF R2b on the surface of innervating processes, resulting in synaptic vesicle clustering, organization, and neurite branching. Although FGF-22 is assumed to be secreted, little can be found in expressing cell culture media. It thought to be bound to 34 kDa FGF-BP1, which is a molecule described as typically associated with cell membrane proteoglycans. Thus, following secretion, FGF-22 could quickly be immobilized by FGF-BP1, only to be released at a later time, or aided by FGF-BP1 in its interaction with FGF R2b. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
参考文献 |
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