| 货号 | BAF3690 |
| 别名 | ACLS; ACLSPAPAPHS; ADD; Bph; GCPS; GLI family zinc finger 3; GLI3 form of 190 kDa; GLI3 full length protein; GLI3-190; GLI3FL; GLI-Kruppel family member GLI3; glioma-associated oncogene family zinc finger 3; Greig cephalopolysyndactyly syndrome; oncogene GLI3; PAP-A; PAPA1; PAPB; PAPBDNA-binding protein; Pdn; PHS; PPDIV; Xt; zinc finger protein GLI3 | 全称 | GLI-Kruppel family member GLI3 |
| 反应种属 | Human/Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human and mouse GLI-3 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) GLI-1 and rhGLI-2 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 2737 (Human); 14634 (Mouse); 140588 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human GLI-3 Met1-Glu479 Accession # P10071 |
| 生物活性 | Human, Mouse |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Human GLI-3 is a 190 kDa transcription factor of the C2H2-typezinc-finger protein family. GLI-3 appears to play a role in limb andbrain development, probably through sonic hedgehog signaling. GLI-3 isregulated by PKA-mediated phosphorylation. Unphosphorylated full-lengthGLI-3 is a transcriptional activator, while phosphorylated GLI-3 iscleaved after amino acid 700 to generate an N-terminal 83 kDatranscriptional repressor. Over the region used as immunogen, humanGLI-3 is 95% identical to the corresponding mouse and canine proteinsequences. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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