| 货号 | BAF3616 |
| 别名 | 1190004M21Rik; FLJ33226; PYGO2; pygopus 2; pygopus homolog 2 (Drosophila); pygopus homolog 2 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Pygopus-2 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human Pygopus-1 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 90780 (Human); 68911 (Mouse) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human Pygopus-2 Met160-Glu336 Accession # Q9BRQ0 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Pygopus-1 and -2 are nuclear transcription co-activators. Structurally they are characterized by an N-terminal homology domain and C-terminal PHD (plant homeodomain) finger Zn2+-binding domain. The PHD finger binds to legless/Bcl9, which in turn binds beta-catenin, a downstream mediator of Wnt signaling. This complex binds TCF/LEF DNA binding proteins. Formation of the quaternary complex is required for the activation of Wnt-responsive genes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
|