| 货号 | BAF3310 |
| 别名 | claspin homolog (Xenopus laevis); claspin homolog; claspin; CLSPN; hClaspin; MGC131612; MGC131613; MGC131615 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Claspin in Western blots. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 63967 (Human); 269582 (Mouse); 298534 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human Claspin Phe1138-Ser1339 Accession # Q9HAW4 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Claspin is a nuclear protein whose expression peaks during S and G2 phases of the cell cycle. Claspin is phosphorylated by ATR in response to DNA damage or replication stress. Phosphorylated Claspin associates with Chk1 via three CKB motifs, and regulates the ATR-dependent phosphorylation and activation of Chk1. Deficits in Claspin expression are associated with failure to undergo cell cycle arrest in response to DNA damage. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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