| 货号 | BAF2927 |
| 别名 | CALR3; calreticulin 2; calreticulin 3; Calreticulin-2; calreticulin-3; cancer/testis antigen 93; Crt2; CRT2calreticulin-2; CT93; FLJ25355; MGC26577 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Calreticulin-2 in Western blots. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 125972 (Human); 73316 (Mouse); 364529 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human Calreticulin-2 Thr20-Leu384 Accession # Q96L12 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Calreticulin is a multifunctional, intracellular calcium-binding protein that is found in most eukaryotic cells. It serves as a key regulator of intracellular free calcium levels. Calreticulin also functions as a lectin-type chaperone in the endoplasmic reticulum (ER). It binds to oligosaccharide residues on newly synthesized glycoproteins to ensure proper folding and retains non-native protein conformers within the ER where they are targeted for degradation. Calreticulin has also been characterized as an inhibitor of steroid hormone-regulated gene expression. Its N-terminal domain, which is termed Vasostatin, binds to the KxFFKR motif located in the DNA-binding domain of nuclear hormone receptors, preventing the receptors from binding to their specific recognition sequence. Additionally, Calreticulin is thought to function as an extracellular lectin and an intracellular mediator of integrin-dependent cell adhesion. Calreticulin-2, an isoform of calreticulin, is expressed in testis, while calreticulin is expressed more widely. The two isoforms of human calreticulin share 53% sequence identity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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