| 货号 | BAF2457 |
| 别名 | CDHS; HUP2; HUP2MGC120384; MGC120381; MGC120382; MGC120383; MGC134778; paired box 3; paired box gene 3 (Waardenburg syndrome 1); paired box homeotic gene 3; paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; Waardenburg syndrome 1; WS1; WS3 | 全称 | Paired Box Gene 3 [Waardenburg Syndrome 1] |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Pax3 in Western blots. In Western blots, less than 5% cross‑reactivity with recombinant human Pax4 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5077 (Human); 18505 (Mouse) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human Pax3 Met1-Ser215 Accession # NP_000429 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Members of the Pax family of transcription factors contain a paired box DNA binding domain and may or may not contain a paired-type homeodomain and/or octapeptide region. Nine Pax genes have been identified in mammals and are divided into four subgroups based on the sequence elements present. Pax genes play a variety of roles during embryogenesis, regulating cell-lineage specification, proliferation, migration, and survival of diverse cell and tissue types. Several of the Pax genes are also expressed in cancers and serve as tumor markers. Pax3 is expressed during early neurogenesis and in developing muscle. Pax3 plays a key role in normal neural development and also works together with Pax7 to regulate the formation and growth of skeletal muscle. Pax3 expression has been observed in melanocyte stem cells where it appears to act as an initiator of melanocyte stem cell differentiation. Pax3 is also implicated melanoma cell survival. There is 98% homology between human and mouse Pax3. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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