| 货号 | BAF2340 |
| 别名 | EC 3.4.24; EC 3.4.24.11; MELL1; membrane metallo-endopeptidase-like 1; Membrane metallo-endopeptidase-like 2MGC119455; MGC119454; MMEL1; MMEL2; NEP2; NEP2(m); NEPIIMGC119456; Neprilysin II; neprilysin-2; NL2; NL2NL1; SEP; soluble secreted endopeptidase; zinc metallopeptidase |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Neprilysin‑2/MMEL1 in Western blots. In Western blots, approximately 5% cross-reactivity with recombinant human (rh) Neprilysin is observed and less than 1% cross-reactivity with rhECE-1 and rhECE-2 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 79258 (Human) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human Neprilysin‑2/MMEL1 Gly78-Trp779 Accession # Q495T6 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Neprilysin-2 is a zinc protease of the Neprilysin family, which also includes Neprilysin, ECE-2, PEX, DINE, Kell and several NEP-like proteins. It is encoded by the human MMEL2 gene and is also known as SEP and Neprilysin-like 1. Highly expressed in testis and nervous system, the cDNA predicts a type II transmembrane protein with a short cytoplasmic tail and a large ectodomain. Both membrane-bound and soluble forms appear comparable with regard to model substrates, pH optima, and inhibitor profiles. Like the closely related Neprilysin, Neprilysin-2 substrates include Tachykinins and Enkephalins. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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