Human IL-36 alpha/IL-1F6 Biotinylated Affinity Purified PAb (50 UG)【科瑞奥博】

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Human IL-36 alpha/IL-1F6 Biotinylated Affinity Purified PAb (50 UG)

货号： BAF1078 基本售价： 5532.3 元规格： -

产品信息

概述
货号	BAF1078
别名	FIL1 epsilon; FIL1; FIL1(EPSILON); FIL1E; IL-1 epsilon; IL1(EPSILON); IL1E; IL-1E; IL-1F6 (FIL-1-epsilon); IL1F6; IL-1F6; IL36A; interleukin 1 family, member 6 (epsilon); interleukin 1, epsilon; Interleukin 36, Alpha; Interleukin-1 epsilon; interleukin-1 family member 6; Interleukin-36 Alpha
全称	Interleukin 36 alpha/Interleukin 1 Family 6
反应种属	Human
应用	Western Blot(0.1 µg/mL) Immunohistochemistry(5-15 µg/mL)
目标/特异性	Detects human IL‑36 alpha /IL‑1F6 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) rhIL-36Ra, rhIL‑37, rhIL-1 alpha, rhIL-1 beta and rhIL-18 is observed.
使用方法	Western Blot: 0.1 µg/mL Immunohistochemistry: 5-15 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	27179 (Human); 54448 (Mouse)
纯化方式	Antigen Affinity-purified
免疫原	E. coli-derived recombinant human IL‑36 alpha /IL‑1F6 Met1-Phe158 Accession # Q9UHA7
生物活性	Human
标记	Biotin
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	Human interleukin 1 family member #6 [IL-1F6; also FIL-1 epsilon (epsilon)] is a member of the IL-1 family of proteins (1‑3). IL-1 family members include IL-1 beta, IL-1 alpha, IL‑1ra, IL-18 and IL-1F5 through F10 (4). All family members show a 12 beta -strand, beta -trefoil configuration, and all family members are believed to have arisen from a common ancestral gene that has undergone multiple duplications (4). IL-1F6 is synthesized as a 158 amino acid (aa) protein that contains no signal sequence, no prosegment and no potential N-linked glycosylation site(s) (1‑3). It appears to be actively secreted (1). When found in cell lysate, it presents as an 18 kDa monomer (2). Human to mouse, full length IL-1F6 has 54% aa identity. Within the family, IL-1F6 is 30% aa identical to IL-1ra, and 27%, 31%, 36%, 46%, 57% and 28% aa identical to IL-1 beta, IL-1F5, F7, F8, F9 and F10, respectively. Cells reported to express IL-1F6 include monocytes, B cells and T cells (1, 4). Notably, IL-1F6 is the only novel IL-1 family member found to be expressed on T-cells. The receptor for IL-1F6 is reported to be a combination of IL-1 Rrp2 and IL-1 RAcP (5). Recombinant IL‑1F6, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NF-kappa B and MAPK in an IL-1 Rrp2 dependent manner. This suggests that IL-1F6 may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Smith, D.E. et al. (2000) J. Biol. Chem. 275:1169. Kumar, S. et al. (2000) J. Biol. Chem. 275:10308. Nicklin, M.J.H. et al. (2002) Genomics. 79:718. Dunn, E. et al. (2001) Trends Immunol. 22:533. Towne, J.E. et al. (2004) J. Biol. Chem. 279:13677.