Phospho-GluR1 (S845) Affinity Purified Polyclonal Ab (150 UL)
货号：
PPS008 基本售价：
5373.6 元 规格：
-
产品信息
概述| 货号 | PPS008 |
| 别名 | AMPA 1; AMPA-selective glutamate receptor 1; GluA1; GLUH1; gluR-1; GLUR1gluR-A; GLURA; GluR-A; gluR-K1; glutamate receptor 1; Glutamate receptor ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA 1; GRIA1; HBGR1; MGC133252 |
全称 | Glutamate Receptor 1 | | 应用 | Western Blot(1:1000 dilution)
|
| 目标/特异性 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| 使用方法 | Western Blot: 1:1000 dilution
|
| 来源 | Polyclonal Rabbit IgG |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 2890 (Human); 14799 (Mouse); 50592 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Phosphopeptide corresponding to amino acid residues surrounding the phospho-S845 of GluR1 |
| 生物活性 | Human, Mouse, Rat, Primate |
| 标记 | Unconjugated |
| 背景 | Rat GluR1 is a 907 amino acid, 4-transmembrane protein that belongs to the glutamate-gated ion channel family. It is one of four AMPA receptor subunits that form a functional heterotetrameric glutamate receptor. GluR1 only interacts with GluR2. GluR1 has two key serine residues in the C-terminal extracellular region. Serine 831 is constitutively unphosphorylated. Upon exposure to a neurotransmitter, it is phosphorylated by CaMKII leading to a potentiation of glutamate-mediated current. Serine 845 is constitutively phosphorylated by Protein Kinase A (PKA). The presence of the phosphate insures membrane localization of the subunit. Following NMDA receptor activation, S845 is dephosphorylated with subsequent subunit internalization. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Glutamate Receptors
- Neurodegenerative Disease
- Neurotransmitter Receptors, Transporters, and Ion Channels
|
参考图片Detection of Phospho-GluR1 (S845) by Western Blot. Western blot of rat hippocampal lysate showing specific immunolabeling of the ~100 kDa GluR1 protein phosphorylated at S845 (Control). The phosphospecificity of this labeling is demonstrated by treatment with 1200 U of lambda Phosphatase ( lambda -PPase) for 30 minutes before being exposed to the Anti-Phospho-GluR1 (S845). The immunolabeling is completely eliminated by treatment with lambda -PPase. |
