| 货号 | PPS016 |
| 简介 | Voltage Gated |
| 别名 | FLJ41162; FLJ42249; FLJ43491; KCNC1; KV3.1; KV4; MGC129855; NGK2; potassium voltage-gated channel subfamily C member 1; potassium voltage-gated channel, Shaw-related subfamily, member 1; voltage-gated potassium channel protein KV3.1; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4 |
| 应用 | Western Blot(1:1000 dilution) Immunohistochemistry(1:1000 dilution) |
| 目标/特异性 | Rat ~100k Voltage Gated Potassium Channel KV3.1-subunit protein phosphorylated at S503 |
| 使用方法 | Western Blot: 1:1000 dilution Immunohistochemistry: 1:1000 dilution |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3746 (Human); 16502 (Mouse) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Phosphopeptide corresponding to amino acid residues surrounding the phospho-S503 of Potassium Channel Kv3.1 |
| 生物活性 | Mouse, Rat |
| 标记 | Unconjugated |
| 背景 | Rat Kv3.1 is a 98 - 110 kDa, six transmembrane glycoprotein that belongs to the C subfamily of the potassium channel family. It generates a voltage-dependent channel selective for potassium that helps determine the electrical property of GABAergic and auditory neurons. The symbol K stands for potassium, v for the molecule’s ligand (i.e. voltage), 3 for the family type that is determined by similarity to fruitfly genes, and 1 for the gene number within the family. There are four family types (Kv1-4) that generate homo- and heterotetramers with themselves and each other. Kv3 family members are associated with very fast activation and deactivation rates of firing. Kv3.1 has two splice forms which differ at their intracellular C-terminus. There is a 98 kDa, 511 amino acid (aa) Kv3.1a, and a 110 kDa, 585 aa Kv3.1b. The two forms may coexist but possibly not multimerize. Kv3.1b has a serine at position 503 that is not shared by Kv3.1a. Phosphorylation by PKC at this site disrupts typical high frequency firing, but generates a coordinated intermediate frequency firing when presented with an intermediate frequency stimulus. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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