概述| 货号 | PPS052 |
| 别名 | DKFZp434P0630; GRASP1; GRASP-1MGC126595; GRIP1 associated protein 1; GRIP1-associated protein 1; GRIPAP1; KIAA1167MGC126593; MPMGp800B12492Q3 |
全称 | GRIP1 Associated Protein 1 | | 反应种属 | Human/Mouse/Rat |
| 应用 | Western Blot(1:1000 dilution)
|
| 目标/特异性 | This antibody is specific for the 95 kDa GRASP in Western blots of rat cerebellar lysates. |
| 使用方法 | Western Blot: 1:1000 dilution
|
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 56850 (Human); 54645 (Mouse); 116493 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Peptide corresponding to amino acid residues from the C‑terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH) |
| 生物活性 | Human, Mouse, Rat, Bovine, Canine |
| 标记 | Unconjugated |
| 背景 | PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Scannevin, R.H. and R.L. Huganir (2000) Nat. Rev. Neurosci. 1:133.
- Ye, B. et al. (2000) Neuron 26:603.
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参考图片Detection of GRASP by Western Blot. Western blot of rat cerebellar lysate showing the specific immunolabeling of the approximately 95 kDa GRASP protein. |
