| 货号 | PPS015 |
| 简介 | Voltage Gated |
| 别名 | delayed rectifier potassium channel protein; KCNB2; KV2.2; potassium channel Kv2.2; potassium voltage-gated channel subfamily B member 2; potassium voltage-gated channel, Shab-related subfamily, member 2; voltage-gated potassium channel subunit Kv2.2 |
| 应用 | Western Blot(1:1000 dilution) Immunohistochemistry(1:1000 dilution) |
| 目标/特异性 | Rodent and Xenopus ~125 kDa Kv2.2 subunit of the Voltage Gated Potassium Channel protein. |
| 使用方法 | Western Blot: 1:1000 dilution Immunohistochemistry: 1:1000 dilution |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 9312 (Human); 98741 (Mouse); 117105 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Peptide from the Kv2.2 subunit region of Xenopus and rodent, conjugated to keyhole limpet hemocyanin (KLH) |
| 生物活性 | Rat, Xenopus |
| 标记 | Unconjugated |
| 背景 | The rat potassium channel Kv2.2 subunit is a 95 - 125 kDa, six transmembrane glycoprotein that belongs to the B subfamily of the potassium channel family. It generates a voltage-dependent channel selective for potassium that helps determine the electrical property of smooth muscle cells, various epithelial cell types and neurons. The symbol K stands for potassium, v for the molecule’s ligand (i.e. voltage), 2 for the family type that is determined by similarity to fruit fly genes, and 2 for the gene number within the family. There are two genes within the Kv2 family (Kv2.1 and Kv2.2) that, although co-expressed, preferentially generate homotetramers rather than heterotetramers. Kv2 family members are associated with action potential repolarization. Kv2.2 is particularly noted for setting the resting membrane potential. Low Kv2.2 activity results in hypersensitive neurons. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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Detection of Potassium Channel Kv2.2 by Western Blot Western blot of rat brain homogenate. As shown in the autoradiograph, the antibody is specific for the ~125 kDa Voltage Gated Potassium Channel, Kv2.2 subunit. The labeling is blocked by preadsorption with the immunizing peptide. |
