Human Common beta Chain Affinity Purified Polyclonal Ab (100 UG)【科瑞奥博】

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Human Common beta Chain Affinity Purified Polyclonal Ab (100 UG)

货号： AF906 基本售价： 4996.9 元规格： -

产品信息

概述
货号	AF906
别名	beta, low-affinity; CD131 antigen; CD131; CDw131; colony stimulating factor 2 receptor, beta, low-affinity(granulocyte-macrophage); CSF2RB; cytokine receptor common subunit beta; GM-CSF R beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; IL-3 R beta; IL3RB; IL-5 R beta; interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3receptor, beta (high affinity)
反应种属	Human
应用	Western Blot(0.1 µg/mL) Flow Cytometry(2.5 µg/10⁶cells)
目标/特异性	Detects recombinant human (rh) Common beta Chain in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) GM-CSF R alpha, rhG-CSF R and rhM-CSF R is observed.
使用方法	Western Blot: 0.1 µg/mL Flow Cytometry: 2.5 µg/10⁶cells
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1439 (Human); 12983 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Three lysine residues in the common beta chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling. Authors: Lei JT, Mazumdar T, Martinez-Moczygemba M J. Biol. Chem., 2011;286(46):40091-103. Species: Human Sample Type: Cell Lysates Application: WB Separate endocytic pathways regulate IL-5 receptor internalization and signaling. Authors: Lei JT, Martinez-Moczygemba M J. Leukoc. Biol., 2008;84(2):499-509. Species: Human Sample Type: Cell Lysates Application: WB
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant human Common beta Chain Gly23-Trp443 Accession # P32927
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	The common beta chain, also known as CD131, is a transmembrane protein that associates with the ligand-specific IL-3 R alpha, IL-5 R alpha, or GM-CSF R alpha proteins to form high affinity receptor complexes. beta c is expressed on a variety of hematopoietic cells.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Common beta Chain Receptor Family Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Tfh Cell Differentiation and Function Human CD Marker Products Mini-review: Interleukin 5 Monocyte Markers Receptors in the Jak/STAT Pathway

参考图片

Detection of Common beta Chain in Human PBL by Flow Cytometry. Human peripheral blood lymphocytes were stained with Goat Anti-Human Common beta Chain Antigen Affinity-purified Polyclonal Antibody (Catalog # AF906, filled histogram) or control antibody (Catalog # AB‑108‑C, open histogram), followed by Fluorescein-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0109).