Human IL-1 Rrp2/IL-1 R6 Affinity Purified Polyclonal Ab (100 UG)【科瑞奥博】

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Human IL-1 Rrp2/IL-1 R6 Affinity Purified Polyclonal Ab (100 UG)

货号： AF872 基本售价： 4996.9 元规格： -

产品信息

概述
货号	AF872
别名	IL-1 R6; IL1RL2; IL-1RL2
全称	Interleukin 1 Receptor-like 2
反应种属	Human
应用	Western Blot(0.1 µg/mL)
目标/特异性	Detects human IL‑1 Rrp2/IL‑1 R6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 15% cross‑reactivity with recombinant rat IL-1 R6 is observed and less than 1% cross-reactivity with recombinant human (rh) IL-1 RI and rhIL-1 RII is observed.
使用方法	Western Blot: 0.1 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	8808 (Human); 107527 (Mouse); 171106 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Structural and functional attributes of the Interleukin-36 receptor Authors: Guanghui Yi J Biol Chem, 2016;0(0):. Species: Human Sample Type: Cell Lysates Application: WB Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor. Authors: Saha S, Singh D, Raymond E, Ganesan R, Caviness G, Grimaldi C, Woska J, Mennerich D, Brown S, Mbow M, Kao C J Biol Chem, 2015;290(39):23997-4006. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant human IL‑1 Rrp2/IL‑1 R6 Asp20-Tyr337 Accession # Q9HB29
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL‑1 R4), IL‑18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9) (1). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain (1). Human IL-1 Rrp2 cDNA encodes a 561 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 318 aa extracellular domain. It shares 67% and 65% amino acid sequence identity with rat and mouse IL 1 Rrp2, respectively. IL-1 Rrp2 is expressed in lung epitheium, brain vasculature, kidney, testis, onocytes, skin-derived keratinocytes, fibroblasts and, to a lesser extent, endothelial cells (2, 3). IL-1 Rrp2 has been shown to mediate the activation of the transcription factor NF kappa B by the IL-1 family ligands IL-1 F6, F8 or F9 (also known as IL-1 epsilon ), with IL-1RAcP as a co‑factor (3, 4). Response to IL-1 F9 is specifically antagonized by IL‑1 F5 (also known as IL-1δ), an IL-1 family ligand that is most closely related to IL-1ra (3). IL-1 Rrp2, IL‑1 F5, and IL-1 F9 are all up-regulated in lesional psoriasis skin, suggesting that the IL-1 Rrp2 mediated signaling pathway may take part in local inflammatory responses (3).
运输条件	Blue Ice
存放说明	-20℃
参考文献	Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229. Lovenberg, T. W. et al. (1996) J. Neuroimmunol. 70:113. Debets, R. et al. (2001) J. Immunol. 167:1440. Towne, J. E. et al. (2004) J. Biol. Chem. 279:13677.