| 货号 | AF153 |
| 别名 | AD3LP; AD4AD3L; AD5; E5-1; EC 3.4.23; EC 3.4.23.-; presenilin 2 (Alzheimer disease 4); presenilin-2; PS-2; PS2CMD1V; PSEN2; PSNL2; STM2STM-2 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Immunohistochemistry(5-15 µg/mL) |
| 目标/特异性 | Detects human Presenilin‑2 N-Terminal Fragment in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human Presenilin‑1 N-Terminal Fragment (aa 1‑80) and recombinant human Presenilin‑2 C-Terminal Fragment (aa 308‑388) is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunohistochemistry: 5-15 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5664 (Human) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human Presenilin-2 Leu2-Thr80 Accession # P49810 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Presenilin‑2 (PS-2 and PSEN2) isa catalytic subunit of the gamma-secretase complex. Presenilin‑2 may play a role inintracellular signaling and gene expression or in linking chromatin to thenuclear membrane. Heterogeneous proteolytic processing of Presenilin‑2 generatesN-terminal (aa 1-297) and C-terminal (aa 298-248) fragments. Presenilin 1 andPresenilin 2 determine gamma-secretase activity, which is responsible forcleaving the amyloid precursor protein (APP). In turn, APP cleavage can produceamyloid-beta, which is the primary component of plaques in the brains ofAlzheimer’s disease patients. Full length, approximately 50 kDa, and theapproximately 30 kDa N-terminal fragment of Presenilin-2 were identified bywestern blotting in extracted rodent pancreas but only the 30 kDa fragment wasdetected in mouse islets and human insulinoma. Within a sequence correspondentto the immunogen, human PS-2 shares 87% aa sequence identity with mouse and ratPS-2. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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