Human CXCL10/IP-10 Polyclonal Ab (1 MG)
货号：
AB-266-PB 基本售价：
4996.9 元 规格：
-
产品信息
概述| 货号 | AB-266-PB |
| 别名 | C7; chemokine (C-X-C motif) ligand 10; CRG-2; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10 |
| 反应种属 | Human |
| 应用 | Western Blot(1 µg/mL)
|
| 目标/特异性 | Detects human CXCL-10/IP-10/CRG-2 in direct ELISAs and Western blots. In direct ELISAs, this antibody shows less than 1% cross‑reactivity with rhENA-78, rhGRO alpha, rhGRO beta, rhGRO gamma, rhI‑309, rmJE, rhMCP-1, rhMIP‑1 alpha, rmMIP‑1 alpha, rhMIP-1 beta, rmMIP-1 beta, and rhRANTES. |
| 使用方法 | Western Blot: 1 µg/mL
|
| 来源 | Reconstitute at 1 mg/mL in sterile PBS. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3627 (Human); 15945 (Mouse) |
| 纯化方式 | Protein A or G purified |
| 免疫原 | E. coli-derived recombinant human CXCL10/IP-10 |
| 内毒素水平 | <0.10 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 1 mg/mL in sterile PBS. |
| 背景 | CXCL10 was originally identified as an IFN-gamma -inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that CXCL10 mRNA is also induced by LPS, IL-1 beta, TNF-alpha, IL-12 and viruses. Additional cell types that have been shown to express CXCL10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. CXCL10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human CXCL10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human CXCL10. Human CXCL10 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted protein. The amino acid sequence of CXCL10 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes. CXCL10 has been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent antitumor effect. A chemokine receptor specific for CXCL10 and Mig has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Loetscher, M. et al. (1996) J. Exp. Med. 184:963.
- Wang, X. et al.(1996) J. Biol. Chem. 271:24286.
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