Rat IFN-beta Polyclonal Ab (500 UG)
货号：
33400-1 基本售价：
4540.8 元 规格：
-
产品信息
概述| 货号 | 33400-1 |
| 别名 | Fibroblast interferon; IFBIFNB; IFF; IFNB1; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956 |
全称 | Interferon beta | | 反应种属 | Rat |
| 应用 | Neutralization |
| 目标/特异性 | Neutralizes both natural and recombinant rat interferon beta. Cross-reactivity with human interferon beta has not been tested. |
| 使用方法 | Neutralization: One neutralization unit is the amount of antiserum required to neutralize one unit of recombinant rat interferon beta (rat IFN-beta ) to a 50% endpoint (one unit corresponds to approximately 15 pg of purified rat IFN-beta ). Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon," in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon about 1 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. As there is no international rat IFN-beta standard,the units are determined with respect to the international reference standard for mouse interferon beta (mouse IFN-beta ) provided by the National Institutes of Health [see Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology (S. Pestka, ed.), Academic Press, New York 119, 14-23]. This material is prepared specifically for effective neutralization of rat IFN-beta.
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| 来源 | Polyclonal Rabbit IgG |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3456 (Human); 15977 (Mouse); 24481 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant rat IFN-beta |
| 生物活性 | Rat |
| 标记 | Unconjugated |
| 溶解方法 | Dissolve contents of the vial by injection of 0.5 ml sterile distilled water. |
| 背景 | Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Ruuls, S.R. et al. (1996) J. Immunol. 157: 5721;
- Zou, L.P. et al. 1999. Neuroscience Res. 56: 123
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