Human/Mouse/Rat Synapsin I Polyclonal Ab (50 UL)
货号：
PPS062 基本售价：
4521.0 元 规格：
-
产品信息
概述| 货号 | PPS062 |
| 别名 | SYN1; SYN1a; SYN1b; Synapsin 1; synapsin IBrain protein 4.1; synapsin-1; SYNI |
| 反应种属 | Human/Mouse/Rat |
| 应用 | Western Blot(1:1000 dilution)
|
| 目标/特异性 | Human, rat, mouse, and bovine ~85 kDa Synapsin I in Western blots. |
| 使用方法 | Western Blot: 1:1000 dilution
|
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 6853 (Human); 20964 (Mouse); 24949 (Rat) |
| 纯化方式 | N/A |
| 免疫原 | Synapsin I |
| 生物活性 | Human, Mouse, Rat, Bovine |
| 标记 | Unconjugated |
| 背景 | Synapsin I is an 85 kDa neuron-specific, O-GlcNAcylated phosphoprotein that interacts with synaptic vesicles and regulates neurotransmitter release. It is concentrated in presynaptic terminals where it anchors synaptic vesicles to the underlying cytoskeleton. Phosphorylation at various sites reduces synapsin I binding to neurosecretory vesicles, making them available for neurotransmitter release. Rat synapsin I is 704 amino acids (aa) in length and contains five domains, named
A-E/F. Domains A-D lie between aa 1-655, while E and F are alternate splice forms. Domain A (28 aa) regulates neurotransmitter release in a phosphorylation-dependent manner. Domains C (328 aa) and E (49 aa) anchor to actin in the synaptic region. Domains B (84 aa) and D (235 aa) promote actin and secretory vesicle interaction, and actin nucleation. Phosphorylation of Ser603 and 566 in domain D, and Ser9 in domain A, reduces the affinity of synapsin I for actin and secretory vesicles. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | |
参考图片Detection of Synapsin I by Western Blot. Western blot of rat hippocampal lysate showing specific immunolabeling of the approximately 78 kDa Synapsin I doublet protein. Immunolabeling blocked by preadsorption of the antibody with the protein used to generate the antibody (not shown). |
