Human IFN-beta Polyclonal Ab (Sheep) (20000 UN)
货号：
31401-1 基本售价：
4322.7 元 规格：
-
产品信息
概述| 货号 | 31401-1 |
| 别名 | Fibroblast interferon; IFBIFNB; IFF; IFNB1; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956 |
全称 | Interferon beta | | 应用 | Neutralization |
| 目标/特异性 | Detects human IFN‑ beta. |
| 使用方法 | Neutralization: One neutralization unit is the amount of antiserum required to neutralize one unit ofhuman interferon beta (Hu-IFN-beta ) to a 50% endpoint. Interferon was titrated with the use of the cytopathic effect inhibitionassay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," J. Virol. 37,755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect InhibitionAssay for Interferon," in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In thisantiviral assay for interferon about 1 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%.The units are determined with respect to the international reference standard for Hu-IFN-beta provided by the NationalInstitutes of Health [see Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology(S. Pestka, ed.), Academic Press, New York 119, 14-23]. This material is prepared specifically for effective neutralizationof Hu-IFN-beta.
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| 来源 | Polyclonal Sheep Serum |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3456 (Human); 15977 (Mouse); 24481 (Rat) |
| 纯化方式 | N/A |
| 免疫原 | Recombinant human IFN‑ beta 1a (expressed in mammalian cells) |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 背景 | Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS. |
| 运输条件 | Dry Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Conventional/Classical Dendritic Cells
- Cytokines and Receptors in Angiogenesis
- IL-10/Interferon Family
- Infectious Diseases
- Plasmacytoid Dendritic Cells
- Th9 Cells
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