Human NAIP Affinity Purified Polyclonal Ab (100 UG)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human NAIP Affinity Purified Polyclonal Ab (100 UG)

货号： AF829 基本售价： 4025.3 元规格： -

产品信息

概述
货号	AF829
别名	baculoviral IAP repeat-containing 1; BIRC1; BIRC1baculoviral IAP repeat-containing protein 1; FLJ18088; FLJ42520; FLJ58811; Neuronal apoptosis inhibitory protein; NLR family, apoptosis inhibitory protein; NLR family, BIR domain containing 1; NLRB1; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domaincontaining 1; psi neuronal apoptosis inhibitory protein; psiNAIP
全称	Neuronal Apoptosis Inhibitor Protein
反应种属	Human
应用	Western Blot(1 µg/mL)
目标/特异性	Detects human NAIP expressed in Sf 21 insect cells.
使用方法	Western Blot: 1 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	4671 (Human); 17940 (Mouse); 191568 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis. Authors: Vassina EM, Yousefi S, Simon D, Zwicky C, Conus S, Simon HU Eur. J. Immunol., 2006;36(7):1975-84. Species: Human Sample Type: Cell Lysates Application: WB Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. Authors: Altznauer F, Martinelli S, Yousefi S, Thurig C, Schmid I, Conway EM, Schoni MH, Vogt P, Mueller C, Fey MF, Zangemeister-Wittke U, Simon HU J. Exp. Med., 2004;199(10):1343-54. Species: Human Sample Type: Whole Cells
纯化方式	Antigen Affinity-purified
免疫原	KLH-coupled human NAIP synthetic peptide YLSLSSTRPDEGLASIIC Accession # NP_004527
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	Neuronal apoptosis inhibitory protein (NAIP; also Baculoviral IAP repeat-containing protein 1) is a 160 kDa member of the inhibitor of apoptosis family of proteins (also known as BIRC proteins). Human NAIP is 1403 amino acids (aa) in length. It contains three distinct regions: an N-terminal cluster of three baculoviral inhibitory repeat (BIR) domains, a central nucleotide binding oligomerization domain (NOD), and a C-terminal leucine-rich repeat (LRR) domain. Human NAIP shares 68% aa identity with mouse NAIP. NAIP is expressed in motor neurons, but not in sensory neurons. It is also expressed in the liver, placenta and to a lesser extent in the spinal cord. NAIP prevents motor neuron apoptosis, and defects in NAIP have been found in individuals with spinal muscular atrophy.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Caspases and Regulators Cysteine Proteases and Regulators ICC / IHC Images: NAIP Inhibitors of Apoptosis (IAPs) and Regulators NOD-like Receptors and the Inflammasome

参考图片

Detection of Human NAIP by Western Blot. Western blot shows lysates of Sf 21 insect cells before (lane 1) and 48 hours post infection with human NAIP (lane 2). PVDF membrane was probed with 1 µg/mL Rabbit Anti-Human NAIP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF829) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band for NAIP was detected at approximately ??? kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 4.