| 货号 | BBA17 |
| 别名 | BB2; CD54 antigen; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; ICAM-1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule 1; Major group rhinovirus receptor; P3.58 | 全称 | Intercellular Adhesion Molecule 1 |
| 反应种属 | Human |
| 应用 | Western Blot(1:1000 dilution) Immunohistochemistry(1:300 dilution) |
| 目标/特异性 | Detects human ICAM‑1/CD54 in direct ELISAs and Western blots. ICAM‑1/CD54 has been screened using CHO cells transfected with cDNAs for ICAM-1, VCAM-1, and E-Selectin. ICAM‑1/CD54 was shown to be only reactive with ICAM-1. |
| 使用方法 | Western Blot: 1:1000 dilution Immunohistochemistry: 1:300 dilution |
| 来源 | Reconstitute in 0.5 mL of sterile water. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3383 (Human); 15894 (Mouse); 25464 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-kappaB-dependent phases. | |
| 纯化方式 | N/A |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant human ICAM‑1/CD54 Extracellular domain |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute in 0.5 mL of sterile water. |
| 背景 | Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1 beta and LPS. Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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