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Human/Mouse Active Caspase-3 Affinity Purified PAb (25 UG)

货号: AF835-SP 基本售价: 2111.7 元 规格: -

产品信息

概述
货号AF835-SP
别名Apopain; apoptosis-related cysteine protease; CASP3; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase-3; CPP32; CPP-32; CPP32B; CPP32SREBP cleavage activity 1; Cysteine protease CPP32; EC 3.4.22; EC 3.4.22.56; LICE-1; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; YAMA
反应种属Human/Mouse
应用Immunocytochemistry(5-15 µg/mL)
目标/特异性Distinguishes apoptotic cells from non-apoptotic cells in immunohistochemistry. Detects the p17 subunit of Caspase-3, but does not detect the precursor form in Western blot. We recommend R&D Systems Affinity Purified Anti-Caspase-3 (Catalog # AF-605-NA) or Monoclonal Anti-Cleaved-Caspase-3 (Catalog # MAB835) for Western blot applications.
使用方法Immunocytochemistry: 5-15 µg/mL
来源Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分
性能
供应商R&D Systems
Entrez Gene IDs836 (Human); 12367 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice
J Neurosci, 2016;36(17):4758-70.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Not Specified
Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density
Authors: SR Berkowicz, TJ Featherby, Z Qu, A Giousoh, NA Borg, JI Heng, JC Whisstock, PI Bird
Mol Autism, 2016;7(0):22.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Frozen
Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary
Authors: M-C De Cian
Oncogene, 2016;0(0):.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Paraffin embedded
Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.
Authors: Jacob F, Yonis A, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt M, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A
PLoS ONE, 2016;11(2):e0145937.
Species: Rat
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture
Authors: F Lorenzi, R Babaei-Jad, J Sheard, B Spencer-De, AS Nateri
Mol Ther Methods Clin Dev, 2016;3(0):16024.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex
Stem Cell Reports, 2016;7(1):69-79.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - PFA fixed
Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs.
Authors: Sharma S, Chintala N, Vadrevu S, Patel J, Karbowniczek M, Markiewski M
J Immunol, 2015;194(11):5529-38.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx.
Authors: Amelkina O, Zschockelt L, Painer J, Serra R, Villaespesa F, Braun B, Jewgenow K
PLoS ONE, 2015;10(11):e0143414.
Species: Feline
Sample Type: Whole Tissue
Application: IHC - paraffin
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Authors: Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M
J Immunol, 2015;195(5):2365-73.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Paraffin embedded
Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout.
Authors: Declercq, Annelies, Chiers, Koen, Van den Broeck, Wim, Dewulf, Jeroen, Eeckhaut, Venessa, Cornelissen, Maria, Bossier, Peter, Haesebrouck, Freddy, Decostere, Annemie
Vet Res, 2015;46(0):25.
Species: Fish - Cyprinus carpio (Carp)
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Exacerbated experimental colitis in TNFAIP8-deficient mice.
Authors: Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen Y
J Immunol, 2015;194(12):5736-42.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Authors: Sesen J, Dahan P, Scotland S, Saland E, Dang V, Lemarie A, Tyler B, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry J, Skuli N
PLoS ONE, 2015;10(4):e0123721.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - Not specified
Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.
Authors: Scott C, Cha K, Rao R, Liddle C, George J, Gunton J
PLoS ONE, 2015;10(3):e0121650.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris.
Authors: Luyet C, Schulze K, Sayar B, Howald D, Muller E, Galichet A
PLoS ONE, 2015;10(3):e0119809.
Species: Mouse
Sample Type: Whole Cells
Application: ICC Fluorescence
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Authors: Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K
Nat Commun, 2015;6(0):6514.
Species: Mouse
Sample Type: Whole Cells
Application: ICC Fluorescence
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
Authors: Brindle N, Joyce J, Rostker F, Lawlor E, Swigart-Brown L, Evan G, Hanahan D, Shchors K
PLoS ONE, 2015;10(4):e0120348.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC-OCT embedded
Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours.
Authors: Petersson, Monika, Reuter, Karen, Brylka, Heike, Kraus, Andreas, Schettina, Peter, Niemann, Catherin
Nat Commun, 2015;6(0):5874.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Not Specified
Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice.
Authors: Wong J, Chen L, Huang Y, Sehba F, Friedel R, Zou H
PLoS ONE, 2015;10(8):e0136967.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
Authors: Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C
J Neurosci, 2015;35(1):4-20.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen
Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells.
Authors: Yen T, Alison M, Goodlad R, Otto W, Jeffery R, Cook H, Wright N, Poulsom R
J Cell Mol Med, 2015;19(2):463-73.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC - paraffin
Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic.
Authors: Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T
PLoS ONE, 2015;10(2):e0116270.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.
Authors: Quereda V, Porlan E, Canamero M, Dubus P, Malumbres M
Cell Death Differ, 2015;23(3):430-41.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.
Authors: Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S
Proc Natl Acad Sci U S A, 2015;112(25):E3207-15.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Not Specified
Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.
Authors: Lindgren G, Ekblad L, Vallon-Christersson J, Kjellen E, Gebre-Medhin M, Wennerberg J
BMC Cancer, 2014;14(0):648.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Not Specified
Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke.
Authors: Mracsko E, Liesz A, Stojanovic A, Lou W, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R
J Neurosci, 2014;34(50):16784-95.
Species: Mouse
Sample Type: Whole Cells
Application: ICC Fluorescence
Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
Authors: Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R
Development, 2014;141(2):448-59.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Not Specified
Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERalpha(+) tumorigenesis.
Authors: Chan S, Rickert C, Vermi W, Sheehan K, Arthur C, Allen J, White J, Archambault J, Lonardi S, McDevitt T, Bhattacharya D, Lorenzi M, Allred D, Schreiber R
Cell Death Differ, 2014;21(2):234-46.
Species: Mouse
Sample Type: tissue
Application: IHC Paraffin-embedded
The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery.
Authors: Ling, Xiang, Bao, Feng, Qian, Hao, Liu, Danxia
BMC Neurosci, 2013;14(0):146.
Species: Rat
Sample Type: tissue
Application: IHC
Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
Authors: Tzeng, Tsai-Ten, Tsay, Huey-Jen, Chang, Luping, Hsu, Chia-Lin, Lai, Tzu-Hsua, Huang, Fong-Lee, Shiao, Young-Ji
J Biomed Sci, 2013;20(0):90.
Species: Mouse
Sample Type: tissue
Application: IHC Fresh
Mechanism of cystogenesis in nephrotic kidneys: a histopathological study.
Authors: Saraga M, Vukojevic K, Krzelj V, Puretic Z, Bocina I, Durdov M, Weber S, Dworniczak B, Ljubanovic D, Saraga-Babic M
BMC Nephrol, 2013;15(0):3.
Species: Human
Sample Type: tissue
Application: IHC - Not specified
Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
Authors: Perez de Castro I, Aguirre-Portoles C, Fernandez-Miranda G, Canamero M, Cowley D, Van Dyke T, Malumbres M
Cancer Res, 2013;73(22):6804-15.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC
Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease.
Authors: Zamli Z, Adams M, Tarlton J, Sharif M
Int J Mol Sci, 2013;14(9):17729-43.
Species: Guinea Pig
Sample Type: tissue
Application: IHC
Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death.
Authors: Wahlin, Karl J, Enke, Raymond, Fuller, John A, Kalesnykas, Giedrius, Zack, Donald J, Merbs, Shannath
PLoS ONE, 2013;8(11):e79140.
Species: Chicken
Sample Type: Whole Tissue
Application: IHC Frozen
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.
Authors: McIntyre A, Patiar S, Wigfield S
Clin. Cancer Res., 2012;18(11):3100-11.
Species: Human
Sample Type: Whole Tissue
Application: IHC
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.
Authors: Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E
Nature, 2012;485(7396):104-8.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen
Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.
Cell Death Differ., 2012;19(11):1761-8.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
Authors: Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, OBrien S, Epstein DM, Koh GY, McDonald DM
Am. J. Pathol., 2011;178(6):2897-909.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC
Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.
Authors: Hernandez-Miranda LR, Cariboni A, Faux C, Ruhrberg C, Cho JH, Cloutier JF, Eickholt BJ, Parnavelas JG, Andrews WD
J. Neurosci., 2011;31(16):6174-87.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Frozen
Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes.
Authors: Perez CJ, Jaubert J, Guenet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F
Am. J. Pathol., 2010;177(4):1958-68.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
ALK1 signaling regulates early postnatal lymphatic vessel development.
Authors: Niessen K, Zhang G, Ridgway JB, Chen H, Yan M
Blood, 2010;115(8):1654-61.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC
Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.
Authors: Hashizume H, Falcon BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM
Cancer Res., 2010;70(6):2213-23.
Species: Human
Sample Type: Whole Tissue
Application: IHC
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
Authors: Sotiropoulou PA, Candi A, Mascre G, De Clercq S, Youssef KK, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC, Blanpain C
Nat. Cell Biol., 2010;12(6):572-82.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
MicroRNA-183 family members regulate sensorineural fates in the inner ear.
Authors: Li H, Kloosterman W, Fekete DM
J. Neurosci., 2010;30(9):3254-63.
Species: Zebrafish
Sample Type: Whole Tissue
Application: IHC
Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung.
Authors: Sozo F, ODay L, Maritz G, Kenna K, Stacy V, Brew N, Walker D, Bocking A, Brien J, Harding R
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(3):L510-8.
Species: Ovine
Sample Type: tissue
Application: IHC Paraffin-embedded
Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease.
Authors: Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sanchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M
J. Clin. Invest., 2009;119(3):636-49.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity.
Authors: Fischer AJ, Scott MA, Ritchey ER, Sherwood P
Glia, 2009;57(14):1538-52.
Species: Chicken
Sample Type: Whole Tissue
Application: IHC Frozen
A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3.
Authors: Stedman A, Lecaudey V, Havis E, Anselme I, Wassef M, Gilardi-Hebenstreit P, Schneider-Maunoury S
Dev. Biol., 2009;327(2):566-77.
Species: Zebrafish
Sample Type: Whole Tissue
Application: IHC
Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain.
Authors: Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW
Neuroscience, 2009;163(3):838-47.
Species: Ovine
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.
Authors: Michaelis M, Bliss J, Arnold SC, Hinsch N, Rothweiler F, Deubzer HE, Witt O, Langer K, Doerr HW, Wels WS, Cinatl J
Clin. Cancer Res., 2008;14(20):6531-7.
Species: Human
Sample Type: Whole Cells
Application: ICC
Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress.
Authors: Boncoeur E, Roque T, Bonvin E, Saint-Criq V, Bonora M, Clement A, Tabary O, Henrion-Caude A, Jacquot J
Am. J. Pathol., 2008;172(5):1184-94.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Authors: Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K
Cancer Res., 2008;68(12):4754-62.
Species: Human
Sample Type: Whole Cells
Application: ICC
Protein C is an autocrine growth factor for human skin keratinocytes.
Authors: Xue M, Campbell D, Jackson CJ
J. Biol. Chem., 2007;282(18):13610-6.
Species: Human
Sample Type: Cell Lysates
Application: WB
Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep.
Authors: Yawno T, Yan EB, Walker DW, Hirst JJ
Neuroscience, 2007;146(4):1726-33.
Species: Ovine
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Cytochemical and ultrastructural study of anoikis and secondary necrosis in enterocytes detached in vivo.
Authors: do Vale A, Costa-Ramos C, Silva DS, Macedo PM, Fernandes R, Sampaio P, Dos Santos NM, Silva MT
Apoptosis, 2007;12(6):1069-83.
Species: Fish - Sea bass
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Gam1-associated alterations of drug responsiveness through activation of apoptosis.
Authors: Wu F, Chiocca S, Beck WT, Mo YY
Mol. Cancer Ther., 2007;6(6):1823-30.
Species: Human
Sample Type: Whole Cells
Application: ICC
Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres.
Authors: Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA
J. Cell Biol., 2007;179(2):277-90.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.
Authors: Blouw B, Haase VH, Song H, Bergers G, Johnson RS
Oncogene, 2007;26(31):4531-40.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC
Cytotoxic action of phorbol esters on human pancreatic cancer cells.
Authors: Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D
Int. J. Cancer, 2007;121(7):1445-54.
Species: Human
Sample Type: Whole Cells
Application: ICC
Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis.
Authors: Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C
Cell Death Differ., 2007;14(12):2047-57.
Species: Mouse
Sample Type: Whole Cells
Application: ICC
Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling.
Authors: Rodriguez-Guzman M, Montero JA, Santesteban E, Ganan Y, Macias D, Hurle JM
Dev. Biol., 2007;302(1):267-80.
Species: Chicken
Sample Type: Whole Tissue
Application: IHC
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Authors: Blanpain C, Lowry WE, Pasolli HA, Fuchs E
Genes Dev., 2006;20(21):3022-35.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC
Evolution of the androgen receptor pathway during progression of prostate cancer.
Authors: Hendriksen PJ, Dits NF, Kokame K, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G
Cancer Res., 2006;66(10):5012-20.
Species: Human
Sample Type: Whole Cells
Application: ICC
Wnt signals mediate a fate decision between otic placode and epidermis.
Authors: Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK
Development, 2006;133(5):865-75.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC
Involvement of the Edar signaling in the control of hair follicle involution (catagen).
Authors: Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA
Am. J. Pathol., 2006;169(6):2075-84.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Fresh
Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.
Authors: Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ
Virology, 2006;349(2):335-46.
Species: Mouse
Sample Type: Whole Cells
Application: ICC
Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells.
Authors: Grzmil M, Kaulfuss S, Thelen P, Hemmerlein B, Schweyer S, Obenauer S, Kang TW, Burfeind P
J. Pathol., 2006;208(3):340-9.
Species: Human
Sample Type: Whole Cells
Application: ICC
Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system.
Authors: Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, J Danser AH, Grosse J, Paul M, Grimm D
Apoptosis, 2006;11(3):347-58.
Species: Porcine
Sample Type: Tissue Homogenates
Application: WB
Helicobacter felis and Helicobacter bizzozeronii induce gastric parietal cell loss in Mongolian gerbils.
Authors: De Bock M, Decostere A, Hellemans A, Haesebrouck F, Ducatelle R
Microbes Infect., 2006;8(2):503-10.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC
Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism.
Authors: Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS
Am. J. Pathol., 2006;169(5):1863-74.
Species: Human
Sample Type: Whole Tissue
Application: IHC Frozen
The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine.
Authors: Geenen K, Favoreel HW, Olsen L, Enquist LW, Nauwynck HJ
Virology, 2005;331(1):144-50.
Species: Porcine
Sample Type: Whole Cells
Application: ICC
Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy.
Authors: Kuo LT, Simpson A, Schanzer A, Tse J, An SF, Scaravilli F, Groves MJ
J. Comp. Neurol., 2005;482(4):320-32.
Species: Rat
Sample Type: Whole Cells
Application: ICC
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
Authors: Salomonsson S, Sonesson SE, Ottosson L, Muhallab S, Olsson T, Sunnerhagen M, Kuchroo VK, Thoren P, Herlenius E, Wahren-Herlenius M
J. Exp. Med., 2005;201(1):11-7.
Species: Rat
Sample Type: Whole Cells
Application: ICC
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
J. Immunol., 2005;175(4):2589-97.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Apoptosis and active caspase-3 expression in human granulosa cells.
Authors: Glamoclija V, Vilovic K, Saraga-Babic M, Baranovic A, Sapunar D
Fertil. Steril., 2005;83(2):426-31.
Species: Human
Sample Type: Whole Cells
Application: ICC
Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro.
Authors: Geenen K, Favoreel HW, Nauwynck HJ
J. Gen. Virol., 2005;86(0):1251-60.
Species: Porcine
Sample Type: Whole Cells
Application: ICC
Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression.
Authors: Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Burfeind P
J. Pathol., 2004;202(1):50-9.
Species: Human
Sample Type: Whole Cells
Application: ICC
Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.
Authors: Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA
Virus Res., 2004;106(1):35-42.
Species: Mouse
Sample Type: Whole Cells
Application: ICC
Evidence of caspase-3 activation in hyposmotic stress-induced necrosis.
Authors: Niquet J, Allen SG, Baldwin RA, Wasterlain CG
Neurosci. Lett., 2004;356(3):225-7.
Species: Rat
Sample Type: Whole Cells
Application: ICC
Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide.
Authors: Schlott T, Taubert H, Fayyazi A, Schweyer S, Bartel F, Korabiowska M, Brinck U
Anticancer Res., 2004;24(6):3819-29.
Species: Human
Sample Type: Whole Cells
Application: ICC
Early events in the anoikis program occur in the absence of caspase activation.
Authors: Wang P, Valentijn AJ, Gilmore AP, Streuli CH
J. Biol. Chem., 2003;278(22):19917-25.
Species: Mouse
Sample Type: Whole Cells
Application: ICC

纯化方式Antigen Affinity-purified
免疫原KLH-coupled human Caspase-3 synthetic peptide
CRGTELDCGIETD
Accession # P42574
生物活性Human, Mouse
标记Unconjugated
溶解方法Reconstitute at 0.2 mg/mL in sterile PBS.
背景

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

运输条件Blue Ice
存放说明4℃
参考文献
  • Apoptosis: Caspase Pathways
  • Apoptosis: Mitochondria Accused of Murder
  • Caspases and Regulators
  • Cell Structure and Signaling Molecules
  • Cysteine Proteases and Regulators
  • ICC / IHC Images: Caspase-3
  • Interactive Pathway: Apoptosis Signaling Pathways
  • Mini-review: Caspases
  • Novel Caspase-8 Roles Revealed by Knockouts
  • Technical Notes: Caspase Antibodies
  • TNF Superfamily Regulators
参考图片
Caspase‑3 in Jurkat Human Cell Line. Caspase‑3 was detected in immersion fixed anti-FAS treated Jurkat human acute T cell leukemia cell line using 0.3 µg/mL Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Caspase‑3 in Jurkat Human Cell Line. Caspase‑3 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with staurosporin using Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (yellow; Catalog # NL004) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.