| 货号 | AF3847-SP |
| 别名 | INT3; neurogenic locus notch homolog protein 4; notch 4; Notch homolog 4; NOTCH3 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Immunocytochemistry(5-15 µg/mL) |
| 目标/特异性 | Detects human Notch-4 Intracellular Domain in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross‑reactivity with recombinant human (rh) Notch-1 Intracellular Domain and rhNotch-2 Intracellular Domain is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunocytochemistry: 5-15 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4855 (Human); 18132 (Mouse); 406162 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Influence of the Notch system in the therapeutic response of American tegumentary leishmaniasis. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human Notch-4 Intracellular Domain Gly1778-Lys2003 Accession # Q99466 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Notch-4 is a 250 kDa heterodimeric membrane protein with a C-terminaltransmembrane fragment covalently linked to an N-terminal extracellularfragment. It functions as a receptor for transmembrane ligands such asthe Jagged and Delta proteins. Upon ligand binding, it undergoessequential proteolytic processing to release the intracellular domain(NICD), which is translocated to the nucleus where it activates targetgenes. In the region used as immunogen, human and mouse Notch-4 share78% amino acid sequence homology. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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