| 货号 | AF3448-SP |
| 别名 | CAK1 antigen; CAK1; megakaryocyte potentiating factor; mesothelin; MPF; MPFSMRP; MSLN; Pre-pro-megakaryocyte-potentiating factor; SMR; soluble MPF mesothelin related protein |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Mesothelin Propeptide/MPF in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross‑reactivity with mature recombinant human Mesothelin is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 10232 (Human); 56047 (Mouse); 60333 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human Mesothelin Propeptide/MPF isoform 1 Arg35-Leu289 Accession # Q13421 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Mesothelin is a 40 kDa, 292 amino acid, GPI-linked glycoprotein found on normal mesothelial cells. It is also highly expressed in pancreatic, gastric and ovarian carcinomas. Mesothelin is synthesized as a preproprotein with a carboxy-terminal hydrophobic pro-region that is removed when a GPI-anchor is added. The amino‑terminal propeptide is cleaved by furin to release a33 kDa soluble protein that is also known as megakaryocyte potentiating factor (MPF). Mouse MPF has been shown to potentiate megakaryocyte colony forming activity of IL-3 in mouse bone marrow culture. The amino acid sequence of human MPF is 55% identical to that of mouse or rat MPF. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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