| 货号 | AF2357-SP |
| 别名 | DKFZp686G21263; F5F8D2; LMAN1IP; MCFD2; multiple coagulation factor deficiency 2; multiple coagulation factor deficiency protein 2; neural stem cell derived neuronal survival protein; Neural stem cell-derived neuronal survival protein; SDNSFF5F8D | 全称 | Stem Cell-derived Neuronal Stem/Progenitor Cell Supporting Factor |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human SDNSF/MCFD2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 35% cross-reactivity with recombinant mouse SDNSF is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 90411 (Human); 193813 (Mouse) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human SDNSF/MCFD2 Glu27-Gln146 Accession # Q8NI22 |
| 内毒素水平 | <0.10 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | SDNSF (stem cell-derived neural stem/progenitor cell supporting factor ), also known as MCFD2 (multiple coagulation factor deficiency 2), was described as a secreted molecule from adult hippocampal neural stem/progenitor cells (ANSC). SDNSF functions as an autocrine/paracrine factor to maintain neurogenesis in the central nervous system. It is a component of the MCDF2-LMAN1 complex that functions as a specific cargo receptor for the ER to Golgi transport of proteins. Mutations in MCFD2 causes factor 5 and factor 8 combined deficiency. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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