| 货号 | AF843-SP |
| 别名 | CMD1T; lamina-associated polypeptide 2; LAP2PRO0868; LEM domain containing 4; LEMD4; MGC61508; Thymopoietin isoform alpha; thymopoietin; Thymopoietin, isoforms beta/gamma; Thymopoietin-related peptide isoform alpha; Thymopoietin-related peptide isoforms beta/gamma; TMPO; TP alpha; TP beta/gamma; TP; TPRP isoform alpha; TPRP isoforms beta/gamma |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human Thymopoietin in direct ELISAs and Western blots. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 7112 (Human) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human Thymopoietin Pro2-Gln187 |
| 内毒素水平 | <0.10 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Thymopoietin (TP alpha; also TMPO, LAP2 alpha and TPRP alpha ) is a 75 kDa member of the LEM family of molecules. It is a nucleoplasmic protein that is widely expressed in cells such as keratinocytes and thymocytes. Here, it interacts with A-type lamins and Rb/retinoblastoma protein, thus participating in cell cycle exit. Human thymopoietin is 694 amino acids (aa) in length. It contains a potential N-terminal “thymopoietin peptide” segment (aa #2-49), a BAF-binding LEM domain (aa #109-153), an NLS (aa #190-196), and a coiled-coil region (aa #558-657). Multiple splice variants exist. All contain the same 188 N-terminal amino acids. Five variants show singular 49, 157, 266, 226, and 60 aa substitutions for the C-terminal 506 amino acids. Over aa #2-187, human thymopoietin shares 93% aa identity with mouse thymopoietin. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |