| 货号 | AF3098-SP |
| 别名 | NI220; RTN4; RTN4A | 全称 | Reticulon 4A |
| 反应种属 | Rat |
| 应用 | Western Blot(0.1 µg/mL) Immunohistochemistry(5-15 µg/mL) |
| 目标/特异性 | Detects rat Nogo-A in direct ELISAs and Western blots. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunohistochemistry: 5-15 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 57142 (Human); 68585 (Mouse); 83765 (Rat) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1beta release through the inhibition of Nogo-A expression. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant rat Nogo-A Glu2-Val172 Accession # Q9JK11 |
| 生物活性 | Rat |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Nogo-A, also known as Reticulon-4, is the longest of four splicevariants of Nogo. It is a CNS myelin-associated neurite outgrowthinhibitor that is highly expressed in oligodendrocytes. Nogo-A issynthesized as an 1163 amino acid protein and lacks a signal peptide.Within conserved C-terminal reticulon homology domain (RHD), twotransmembrane domains, which are separated by a 66 amino acidextracellular loop, exist. Both the N-terminal domain and the 66 aminoacid domain (Nogo-66) can be detected on the cell surface and showneurite outgrowth inhibitory activity. The amino acid sequence of ratNogo-A N-terminal domain is 76% identical to that of human Nogo-A.Within the RHD domain, rat Nogo-A shares 99% and 97% amino acidsequence identity with mouse and human Nogo, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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