| 货号 | AF5347-SP |
| 别名 | antitrypsin), member 12; member 12; OL-64; OL-64Visceral adipose-specific serpin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase; serpin A12; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin); Vaspin; Visceral adipose tissue-derived serine protease inhibitor |
| 反应种属 | Rat |
| 应用 | Western Blot(0.1 µg/mL) Immunoprecipitation(25 µg/mL) |
| 目标/特异性 | Detects rat Serpin A12 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross‑reactivity with recombinant human Serpin A12 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunoprecipitation: 25 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 145264 (Human); 68054 (Mouse); 191570 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant rat Serpin A12 Leu20-Pro411 Accession # Q8R4Z1 |
| 生物活性 | Rat |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Serpin A12 (serine proteinase inhibitor-clade A #12; also vaspin) is a 45‑50 kDa, secreted member of the alpha 1-antitrypsin (clade A)-subfamily, Serpin superfamily of protease inhibitors. It is produced by visceral and subcutaneous adipocytes, plus adipocyte-derived stem cells during obesity or diabetes. The presence of vaspin reverses insulin-resistance. Its molecular target is unknown, but it may antagonize the action of proteases that impair the action of insulin. Rat Serpin A12 is 411 amino acids (aa) in length. It contains a 20 aa signal sequence and a 391 aa mature region. A potential “active” inhibitor site lies between Gly364 and Pro389. Mature rat Serpin A12 shares 62% and 88% aa identity with human and mouse Serpin A12, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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