| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages
Sci Rep, 2016;6(0):29673.
Species: Mouse
Sample Type: In vitro
Application: in vitro
MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
TAM receptors regulate multiple features of microglial physiology
Authors: L Fourgeaud, PG Través, Y Tufail, H Leal-Baile, ED Lew, PG Burrola, P Callaway, A Zagórska, CV Rothlin, A Nimmerjahn, G Lemke
Nature, 2016;532(7598):240-4.
Species: Mouse
Sample Type: Tissue Lysate
Application: WB
Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue dendritic cells.
Authors: Kuan E, Ivanov S, Bridenbaugh E, Victora G, Wang W, Childs E, Platt A, Jakubzick C, Mason R, Gashev A, Nussenzweig M, Swartz M, Dustin M, Zawieja D, Randolph G
J Immunol, 2015;194(11):5200-10.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration.
Authors: Levy O, Calippe B, Lavalette S, Hu S, Raoul W, Dominguez E, Housset M, Paques M, Sahel J, Bemelmans A, Combadiere C, Guillonneau X, Sennlaub F
EMBO Mol Med, 2015;7(2):211-26.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis.
Authors: Nascimento M, Huang S, Smith A, Everts B, Lam W, Bassity E, Gautier E, Randolph G, Pearce E
PLoS Pathog, 2014;10(8):e1004282.
Species: Mouse
Sample Type: Whole Cells
Application: Flow
Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.
Authors: Brown JE, Krodel M, Pazos M
PLoS ONE, 2012;7(5):e36800.
Species: Rat
Sample Type: Cell Lysates
Application: IP
Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells.
Authors: Galvan MD, Foreman DB, Zeng E
J. Immunol., 2012;188(8):3716-23.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.
J. Cell. Sci., 2012;91(6):921-32.
Species: Mouse
Sample Type: In Vivo
Application: In vivo
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.
Authors: Zhu D, Wang Y, Singh I
Blood, 2010;115(23):4963-72.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
Authors: Zhong Z, Wang Y, Guo H, Sagare A, Fernandez JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV
J. Neurosci., 2010;30(46):15521-34.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice.
Authors: Thorp E, Cui D, Schrijvers DM, Kuriakose G, Tabas I
Arterioscler. Thromb. Vasc. Biol., 2008;28(8):1421-8.
Species: Mouse
Sample Type: Whole Tissue
Application: IHC Paraffin-embedded
Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.
Authors: Chang Y, Finnemann SC
J. Cell. Sci., 2007;120(0):3053-63.
Species: Rat
Sample Type: Cell Lysates
Application: IP
A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.
Authors: Sather S, Kenyon KD, Lefkowitz JB, Liang X, Varnum BC, Henson PM, Graham DK
Blood, 2007;109(3):1026-33.
Species: Mouse
Sample Type: Cell Lysates
Application: WB
Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.
Authors: Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA
J. Thromb. Haemost., 2005;3(4):733-41.
Species: Mouse
Sample Type: Whole Cells
Application: Flow |
| 背景 | Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1, 2). |
