Mouse SorCS2 Affinity Purified Polyclonal Ab (25 UG)【科瑞奥博】

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Mouse SorCS2 Affinity Purified Polyclonal Ab (25 UG)

货号： AF4237-SP 基本售价： 1378.1 元规格： -

产品信息

概述
货号	AF4237-SP
别名	KIAA1329VPS10 domain receptor protein; sortilin-related VPS10 domain containing receptor 2; VPS10 domain-containing receptor SorCS2
全称	Sortilin-related VPS10 Domain Containing Receptor 2
反应种属	Mouse
应用	Western Blot(0.1 µg/mL) Immunohistochemistry(5-15 µg/mL)
目标/特异性	Detects mouse SorCS2 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) SorCS2 and less than 5% cross-reactivity with rhSorCS1 and recombinant mouse SorCS1 is observed.
使用方法	Western Blot: 0.1 µg/mL Immunohistochemistry: 5-15 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	57537 (Human); 81840 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear Authors: A Forge, RR Taylor, SJ Dawson, M Lovett, DJ Jagger PLoS Genet, 2017;13(3):e1006692. Species: Mouse Sample Type: Whole Tissue Application: IHC - Fresh SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease Authors: Q Ma, J Yang, TA Milner, JG Vonsattel, ME Palko, L Tessarollo, BL Hempstead JCI Insight, 2017;2(9):. Species: Mouse Sample Type: Whole Tissue Application: IHC Frozen Prions amplify through degradation of the VPS10P sorting receptor sortilin Authors: K Uchiyama, M Tomita, M Yano, J Chida, H Hara, NR Das, A Nykjaer, S Sakaguchi PLoS Pathog., 2017;13(6):e1006470. Species: Mouse Sample Type: Cell Lysates Application: WB
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant mouse SorCS2 Ala118-Gly1078 Accession # Q9EPR5
生物活性	Mouse
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	Mouse SorCS2 is a 110‑130 kDa member of the Vps10p (vacuolar protein sorting 10 protein)-D family of sorting receptors. It is synthesized as a 1159 amino acid (aa) preproprecursor that undergoes proteolytic processing to generate a 1042 aa mature type I transmembrane receptor. The extracellular domain shows an imperfect LRR and a Vps10p domain. SorCS2 is plasma membrane expressed and may undergo proteolytic cleavage. Over aa 118-1078, mouse SorCS2 is 88% and 98% aa identical to human and rat SorCs2, respectively.
运输条件	Blue Ice
存放说明	4℃
参考文献	ICC / IHC Images: SorCS2 Neurotrophic Factors and Receptors VEGF Family VPS10P-domain Family

参考图片

SorCS2 in Mouse Brain. SorCS2 was detected in perfusion fixed frozen sections of mouse brain using Sheep Anti-Mouse SorCS2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4237) at 15 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # NL010) and counterstained with DAPI (blue). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

SorCS2 in Mouse Brain. SorCS2 was detected in perfusion fixed frozen sections of mouse brain using Sheep Anti-Mouse SorCS2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4237) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.