| 货号 | AF3685-SP |
| 别名 | amyloid beta (A4) precursor-like protein 2; amyloid precursor protein homolog HSD-2; Amyloid protein homolog; amyloid-like protein 2; APLP-2; APPH; APPHCDEI box-binding protein; APPL2; CDEBP; WALPLP2; YWK-II | 全称 | Amyloid Beta [A4] Precursor-like Protein 2 |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects mouse APLP-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) APLP-2 is observed and less than 1% cross-reactivity with rhAPLP-1 and recombinant mouse APLP-1 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 334 (Human); 11804 (Mouse); 64312 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse APLP-2 Leu37-Ser624 Accession # AAH52396 |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Mouse APLP-2 is a 120-170 kDa (695 aa) member of the APP family of typeI transmembrane (TM) proteins. Its 595 aa extracellular region hasmultiple domains, including an N-terminal Cys-rich domain, anAsp/Glu-rich acidic region, and a membrane proximal linker region thatcontains a GAG attachment site. Several alternatively spliced APLP-2isoforms have been reported. APLP-2 is proteolytically cleaved by MMPsand secretases and forms both homodimers and heterodimers with APP andAPLP-1. Over the range used as immunogen, mouse APLP-2 shares 97% and91% aa sequence identity with rat and human ALPL-2, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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