| 货号 | AF3533-SP |
| 别名 | DKFZp547G0910; Pygo1; pygopus 1; pygopus homolog 1 (Drosophila); pygopus homolog 1; pygopus-like protein 1 |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects mouse Pygopus-1 in direct ELISAs and Western blots. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 26108 (Human); 72135 (Mouse) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant mouse Pygopus-1 Ser2-Ala417 Accession # Q9D0P5 |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Pygopus (the name of a legless Australian lizard) is a 45 kDatranscription co-activator that functions in the Wnt signaling pathway.Mouse Pygopus-1 is a nuclear protein that is synthesized as a 417 aminoacid residue protein that has the conserved N-terminal homology domain(NHD) and the C-terminal PHD (Plant homeodomain) finger Zn2+-bindingdomain. A nuclear localization signal is present within the NHD. ThePHD finger of Pygopus binds to Legless/Bcl9, which in turn binds beta -Catenin, which recruits TCF/LEF DNA binding proteins. Formation ofthe quaternary complex is required for Wnt signaling. Mouse and humanPygopus-1 share 87% amino acid sequence homology. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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