| 货号 | AF3454-SP |
| 别名 | C-alpha-formyglycine-generating enzyme 2; C-alpha-formylglycine-generating enzyme 2; DKFZp566I1024; DKFZp686I1024; DKFZp686L17160; DKFZp781L1035; FGE2; MGC99485; paralog of the formylglycine-generating enzyme; pFGE; sulfatase modifying factor 2; sulfatase-modifying factor 2 |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) Immunoprecipitation(25 µg/mL) |
| 目标/特异性 | Detects mouse Sulfatase Modifying Factor 2/SUMF2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human (rh) SUMF2 and less than 5% cross-reactivity with rhSUMF1 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunoprecipitation: 25 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 25870 (Human) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse Sulfatase Modifying Factor 2/SUMF2 Gln34-Leu308 Accession # Q8BPG6 |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Mouse SUMF2 is a 30 kDa member of the sulfatase-modifying factor family. It is synthesized as a 275 amino acid (aa) glycoprotein that is localized to the ER. It contains multiple calcium-binding sites and three (sub)domains of varying length and ill-defined structure (aa 38‑298). There is one potential alternate start site at aa 118 that would generate a 190 aa precursor. The founding family member, SUMF1, posttranslationally activates newly synthesized sulfatases by converting a Cysteine to formylGly in the catalytic site. SUMF2 apparently has no such activity. It forms homodimers and heterodimers with SUMF1. As a heterodimer, it downmodulates SUMF1 activity. Mature mouse SUMF2 is 85% and 93% aa identical to human and rat SUMF2, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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