| 货号 | AF2885-SP |
| 别名 | latent transforming growth factor beta binding protein 4; LTBP4; LTBP-4; LTBP4L; LTBP4S |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects mouse Latent TGF‑ beta bp4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) LTBP-1 and rhLTBP-2 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 8425 (Human) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Latent TGF-beta binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. | |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse Latent TGF‑ beta bp4 isoform 1 Ser25-Ala1666 (Arg542-Pro547) Accession # AAI41006 |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | LTBP-4 is a 170 kDa extracellular glycoprotein that belongs to the LTBP/fibrillin family. These proteins contain a conserved pattern of eight cysteine residues (8Cys) and EGF-like domains. Mouse LTBP-4 isoform 1 is synthesized as 1666 amino acid residues and contains 14 EGF-like motifs and three 8Cys, the 3rd of which is responsible for disulfide-association with the latency-linked associated peptide (LAP) of latent TGF-beta 1. LTBP-4 is expressed in multiple tissues and is involved in the assembly, secretion and targeting of latent TGF-beta to sites where it can be activated. Two additional splice isoforms that differ from isoform 1 in residues 60‑150 or 67‑150, have been described. Human and mouse LTBP-4 share 90% amino acid sequence homology. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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