Human c-Fos Affinity Purified Polyclonal Ab (25 UG)【科瑞奥博】

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Human c-Fos Affinity Purified Polyclonal Ab (25 UG)

货号： AF7254-SP 基本售价： 1378.1 元规格： -

产品信息

概述
货号	AF7254-SP
别名	activator protein 1; AP-1; cellular oncogene c-fos; Cellular oncogene fos; C-FOS; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; proto-oncogene c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
全称	FBJ/Finkel–Biskis–Jinkins Murine Osteosarcoma Viral Oncogene Homolog
反应种属	Human
应用	Western Blot(0.2 µg/mL)
目标/特异性	Detects human c-Fos in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human Fos-B is observed.
使用方法	Western Blot: 0.2 µg/mL
来源	Sterile PBS to a final concentration of 0.2 mg/mL.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2353 (Human); 14281 (Mouse); 314322 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Osteocytes produce interferon-beta as a negative regulator of osteoclastogenesis. Authors: Hayashida C, Ito J, Nakayachi M, Okayasu M, Ohyama Y, Hakeda Y, Sato T J Biol Chem, 2014;289(16):11545-55. Species: Mouse Sample Type: Cell Lysates Application: WB
纯化方式	Antigen Affinity-purified
免疫原	E. coli-derived recombinant human c-Fos Met1-Leu132 Accession # P01100
生物活性	Human
标记	Unconjugated
溶解方法	Sterile PBS to a final concentration of 0.2 mg/mL.
背景	Cellular oncogene fos (c-Fos) is one of four Fos family proteins that associate with Jun family proteins to form the AP-1 transcription factor complex. It is thought to have an important role in signal transduction, cell proliferation and differentiation. Cellular oncogene fos (c-Fos) is constitutively sumoylated by SUMO1, SUMO2 and SUMO3. Within aa 1-132, human c-Fos shares 92% aa sequence identity with mouse and rat c-Fos.
运输条件	Blue Ice
存放说明	4℃
参考文献	Apoptosis Transcription Factors and Regulators Basic Leucine Zipper (bZIP) Transcription Factors Cell Cycle Chemokine Receptor Intracellular Signaling C-type Lectin Receptors IL-1 Family IL-17 Family NOD-like Receptors and the Inflammasome PDGF Family Positive Regulators of the Jak/STAT Pathway TNF Superfamily Regulators Toll-Like Receptors Transcription Factors in the Akt Pathway VEGF Family Wnt Intracellular Signaling

参考图片

Detection of Human c-Fos by Western Blot. Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line untreated (-) or treated (+) with 200 nM PMA for 4 hours. PVDF membrane was probed with 0.2 µg/mL of Sheep Anti-Human c-Fos Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7254) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for c-Fos at approximately 62 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.