| 货号 | AF706-SP |
| 别名 | CD116 antigen; CD116; CDw116; colony stimulating factor 2 receptor alpha subunit; colony stimulating factor 2 receptor, alpha, low-affinity(granulocyte-macrophage); CSF2R; CSF2RA; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF receptor alpha subunit; GMCSFR; GM-CSF-R-alpha; GMCSFR-alpha; GMR; GMR-alpha; granulocyte-macrophage colony-stimulating factor receptor alpha chain; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; MGC3848; MGC4838 | 全称 | Granulocyte Macrophage Growth Factor Receptor alpha |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Flow Cytometry(2.5 µg/106cells) |
| 目标/特异性 | Detects human GM‑CSF R alpha in direct ELISAs and Western blots. |
| 使用方法 | Western Blot: 0.1 µg/mL Flow Cytometry: 0.25 µg/106cells |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 1438 (Human); 12982 (Mouse) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human GM-CSF R alpha Extracellular domain |
| 内毒素水平 | <0.10 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | The high affinity receptor for granulocyte-macrophage colony stimulating factor (GM-CSF) consists of two subunits; an 80 kDa cytokine-specific alpha-subunit (CD116), and a 120 kDa non-specific, signal transducing beta-subunit (CD131). Analogous with other cytokine signaling mechanisms, CD131 is also shared with the cytokine specific alpha-subunits of the IL-3 and IL-5 receptors. In the absence of CD131, the CD116 alpha-subunit binds GM-CSF with low affinity. GM-CSF receptors are highly expressed on neutrophils, monocytes, oligodendrocytes, megakaryocytes, eosinophils, and myeloid leukemia cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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