Human/Feline IL-23 p19 Affinity Purified Polyclonal Ab (25 UG)【科瑞奥博】

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Human/Feline IL-23 p19 Affinity Purified Polyclonal Ab (25 UG)

货号： AF6238-SP 基本售价： 1378.1 元规格： -

产品信息

概述
货号	AF6238-SP
别名	IL-23; IL23A; IL-23A; IL-23-A; IL-23p19; IL23P19P19; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T-cell activation; MGC79388; SGRF; SGRFIL-23 subunit alpha
全称	Interleukin 23
反应种属	Human/Feline
应用	Western Blot(1 µg/mL)
目标/特异性	Detects human and feline IL-23 p19 in direct ELISAs and Western blots. In direct ELISAs, approximately 60% cross-reactivity with recombinant canine IL-23 p19 is observed and approximately 30% cross-reactivity with recombinant mouse IL-23 p19 is observed.
使用方法	Western Blot: 1 µg/mL
来源	Sterile PBS to a final concentration of 0.2 mg/mL.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	51561 (Human); 83430 (Mouse)
纯化方式	Antigen Affinity-purified
免疫原	E. coli-derived recombinant feline IL-23 p19 Arg26-Arg185 Accession # ABB01676
生物活性	Human, Feline
标记	Unconjugated
溶解方法	Sterile PBS to a final concentration of 0.2 mg/mL.
背景	IL-23 p19 (Interleukin 23 p19; also IL-23 alpha) is an 18-20 kDa (estimated) member of the IL-6 superfamily of molecules. It is disulfide-bonded to p40 to form IL-23. IL-23 is secreted by immune-related cell types such as keratinocytes, dendritic cells, macrophages, microglia and monocytes, often following TLR stimulation. It appears to drive Th17 cell development by inhibiting T-bet and FoxP3 production, and to reduce IL-12-mediated IFN-gamma production by CD4+, CD8+ and NK cells. Based on human, mature feline IL-23 p19 is 160 amino acids (aa) in length. It is a alpha -helical molecule that utilizes Cys80 to form an interchain disulfide bond with IL-12 p40. IL-23 p19 does not appear to be released unless dimerized to p40. There are no potential N-linked glycosylation sites on p19. Mature feline IL-23 p19 (aa 26-185) shares 87% aa identity with human IL-23 p19.
运输条件	Blue Ice
存放说明	4℃
参考文献	Conventional/Classical Dendritic Cells IL-12 Family IL-23: A New Composite Cytokine Inflammatory/Monocyte-derived Dendritic Cells LTi Cells Macrophage Activation Markers Multiple Sclerosis and Myelin Related Molecules NCR+ILC3 NCR-ILC3 Neuroinflammation T Cell Cytokine Signaling Th17 Cells The IL-12 Family of Cytokines & Mechanisms of Intestinal Inflammation

参考图片

Detection of Human IL‑23 p19 by Western Blot. Western blot shows lysates of Hs 294T human melanoma cell line. PVDF Membrane was probed with 1 µg/mL of Feline IL‑23 p19 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6238) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for IL‑23 p19 at approximately 27 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.