Human/Mouse IkB-beta Affinity Purified Polyclonal Ab (25 UG)【科瑞奥博】

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Human/Mouse IkB-beta Affinity Purified Polyclonal Ab (25 UG)

货号： AF5225-SP 基本售价： 1378.1 元规格： -

产品信息

概述
货号	AF5225-SP
别名	beta; IkappaBbeta; I-kappa-B-beta; ikB-B; IkB-beta; IKBBikB-beta; NF-kappa-B inhibitor beta; NF-kappa-BIB; NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9; TRIP9ikappaBbeta
全称	I-kappa-B-beta
反应种属	Human/Mouse
应用	Western Blot(1 µg/mL)
目标/特异性	Detects endogenous human and mouse I kappa B-beta in Western blots.
使用方法	Western Blot: 1 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	4793 (Human); 18036 (Mouse); 81525 (Rat)
纯化方式	Antigen Affinity-purified
免疫原	E. coli-derived recombinant mouse I kappa B-beta Met1-Ala359 Accession # Q60778
生物活性	Human, Mouse
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	I kappa B-beta (I kappa B-beta; also NF-kappa-BIB) is a 46 kDa member of the I kappa B-beta inhibitor family of proteins. It is highly expressed in testicular spermatids, and serves to block NF-kappa B activity. This is accomplished by I kappa B-beta binding to either an NF-kappa B dimer, or a kappa B-Ras:NF-kappa B dimer complex. Mouse I kappa B-beta is 359 amino acids (aa) in length it contains a signal response region (aa 1‑50), six ankyrin repeats (aa 54‑308) and a PEST domain whose phosphorylation at Ser312 and Ser314 blocks NF‑ kappa B activation. Phosphorylation at Ser19 and Ser23 promotes I kappa B‑ beta ubiquitination and degradation. Full‑length mouse I kappa B‑ beta shares 94% and 84% aa identity with rat and human I kappa B-beta, respectively.
运输条件	Blue Ice
存放说明	4℃
参考文献	Chemokine Receptor Intracellular Signaling C-type Lectin Receptors IL-1 Family IL-17 Family NOD-like Receptors and the Inflammasome PDGF Family RIG-I-like Receptors Stem Cell Transcription Factor Regulators Toll-Like Receptors Transcription Factors and Regulators Transcriptional Co-Repressors

参考图片

Detection of Mouse IkB-beta by Western Blot. Western blot shows lysates of NIH‑3T3 mouse embryonic fibroblast cell line, BaF3 mouse pro‑B cell line, M1 mouse myeloid leukemia cell line. PVDF membrane was probed with 1 µg/mL of Human/Mouse IkB-beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5225) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for IkB-beta at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.