| 货号 | AF4974-SP |
| 别名 | a disintegrin and metalloproteinase domain 23; ADAM metallopeptidase domain 23; disintegrin and metalloproteinase domain-containing protein 23; MDC3; MDC-3; MDC3ADAM 23; MDC-L; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3 | 全称 | A Disintegrin and Metalloproteinase Domain 23 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Immunoprecipitation(25 µg/mL) |
| 目标/特异性 | Detects human ADAM23 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) ADAM8, rhADAM9, and rhADAM22 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunoprecipitation: 25 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 8745 (Human); 23792 (Mouse); 301460 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant human ADAM23 Ser60-His585 Accession # O75077 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | ADAM23 (a disintegrin and metalloprotease domain 23; also MDC3) is a 100 kDa member of the M12B peptidase family of enzymes. It is expressed on fetal neurons in the hippocampus and cerebellum and serves as a counter‑receptor for alpha vbeta3 integrin. The human ADAM23 proprecursor is a 773 amino acid (aa) type I transmembrane (TM) protein. It contains a 227 aa cleavable proregion (aa 60‑286) and a 506 aa extracellular domain (ECD) (aa 287‑792) that is part of a 70 kDa mature molecule. The ECD contains a nonfunctional metalloprotease domain (aa 299‑494), an integrin‑binding disintegrin region (aa 511‑585) and a Cys‑rich domain (aa 589‑611). Two splice variants exist. One shows an in‑frame 46 aa substitution for aa 787‑832 that generates a soluble form, while a second shows an in‑frame 31 aa TM substitution for aa 787‑817. Over aa 1‑585, human ADAM23 is 92% aa identical to mouse ADAM23. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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