Human CD157 Affinity Purified Polyclonal Ab (25 UG)【科瑞奥博】

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Human CD157 Affinity Purified Polyclonal Ab (25 UG)

货号： AF4736-SP 基本售价： 1378.1 元规格： -

产品信息

概述
货号	AF4736-SP
别名	ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; bone marrow stromal cell antigen 1; BP-3; BST1; BST-1; cADPr hydrolase 2; CD157 antigen; CD157; Cyclic ADP-ribose hydrolase 2; EC 3.2.2.5; NAD(+) nucleosidase
全称	Cluster of Differentiation 157
反应种属	Human
应用	Western Blot(1 µg/mL)
目标/特异性	Detects human CD157 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 10% cross-reactivity with recombinant mouse CD157 is observed.
使用方法	Western Blot: 1 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	683 (Human); 12182 (Mouse); 81506 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Binding of CD157 protein to fibronectin regulates cell adhesion and spreading. Authors: Morone S, Augeri S, Cuccioloni M, Mozzicafreddo M, Angeletti M, Lo Buono N, Giacomino A, Ortolan E, Funaro A J Biol Chem, 2014;289(22):15588-601. Species: Human Sample Type: protein Application: ELISA Capture
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant human CD157 Gly29-Lys292 Accession # Q10588
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	CD157, also known as bone marrow stromal cell antigen 1 (BST-1), is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family (1). CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth (2, 3). Along with CD38, CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities (2). It may play a role in rheumatoid arthritis (RA) due to its enhanced expression in RA‑derived bone marrow stromal cell lines (3). CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule (4).
运输条件	Blue Ice
存放说明	4℃
参考文献	Hussain, A. M. M. et al. (1998) Protein Express. Purif. 12:133. Sato, A. et al. (1999) Biochem. J. 337:491. Kaisho, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91:5325. Ortolan, E. et al. (2002) Cell Biochem. Funct. 20:309.

参考图片

Detection of Human CD157 by Western Blot. Western blot shows lysates of human kidney (cortex) tissue. PVDF Membrane was probed with 1 µg/mL of Sheep Anti-Human CD157 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4736) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for CD157 at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.