Human/Mouse/Rat PAK6 Affinity Purified Polyclonal Ab (25 UG)【科瑞奥博】

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Human/Mouse/Rat PAK6 Affinity Purified Polyclonal Ab (25 UG)

货号： AF4265-SP 基本售价： 1378.1 元规格： -

产品信息

概述
货号	AF4265-SP
别名	EC 2.7.11; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated kinase 6; p21-activated protein kinase 6; PAK-5; PAK5EC 2.7.11.1; PAK-6; serine/threonine-protein kinase PAK 6
全称	p21/Cdc42/Rac1-activated Kinase 6
反应种属	Human/Mouse/Rat
应用	Western Blot(2 µg/mL)
目标/特异性	Detects endogenous human, mouse and rat PAK6 in Western blots.
使用方法	Western Blot: 2 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	56924 (Human); 214230 (Mouse); 296078 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. INPP4B suppresses prostate cancer cell invasion. Authors: Hodgson, Myles C, Deryugina, Elena I, Suarez, Egla, Lopez, Sandra M, Lin, Dong, Xue, Hui, Gorlov, Ivan P, Wang, Yuzhuo, Agoulnik, Irina U Cell Commun Signal, 2014;12(0):61. Species: Human Sample Type: Cell Lysate Application: WB Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients. Authors: Kwek, Serena S, Dao, Vinh, Roy, Ritu, Hou, Yafei, Alajajian, David, Simko, Jeffrey, Small, Eric J, Fong, Lawrence J Immunol, 2012;189(7):3759-66. Species: Human Sample Type: Cell Lysates Application: WB
纯化方式	Antigen Affinity-purified
免疫原	E. coli-derived recombinant human PAK6 Met1-Arg137 Accession # Q9NQU5
生物活性	Human, Mouse, Rat
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	As downstream targets of the Rho GTPases, the p21-activated kinase (PAK) family of serine/threonine kinases regulates the organization of the actin cytoskeleton in mammalian cells. The PAK family is structurally categorized in two groups, each with three members: group I PAK1-3; and group II PAK4-6. PAK6 is expressed most highly in brain and testes, with lower levels in multiple tissues. Both MKK6 and p38 MAPK activate PAK6, suggesting a role for this kinase in the cellular stress response.
运输条件	Blue Ice
存放说明	4℃
参考文献	Chemokine Receptor Intracellular Signaling Intracellular Kinases

参考图片

Detection of Human/Mouse/Rat PAK6 by Western Blot. Western blot shows lysates of HT-29 human colon adenocarcinoma cell line, A431 human epithelial carcinoma cell line, KG-1 human acute myelogenous leukemia cell line, and CH-1 mouse B cell lymphoma cell line. PVDF membrane was probed with 2 µg/mL of Human/Mouse/Rat PAK6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4265) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for PAK6 at approximately 75 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 3.