| 货号 | AF3765-SP |
| 别名 | Acute myeloid leukemia 2 protein; AML2; AML2SL3/AKV core-binding factor alpha C subunit; CBFA3; CBFA3MGC16070; CBF-alpha-3; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2A3; PEBP2A3FLJ34510; PEBP2AC; PEBP2-alpha C; runt domain, alpha subunit 3; runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; transcription factor AML2 | 全称 | Runt-related Transcription Factor 3 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) Immunocytochemistry(5-15 µg/mL) |
| 目标/特异性 | Detects human RUNX3/CBFA3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody shows less than 1% cross‑reactivity with recombinant human (rh) CBFA1 and rhCBFA2. |
| 使用方法 | Western Blot: 0.1 µg/mL Immunocytochemistry: 5-15 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 864 (Human); 12399 (Mouse); 156726 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human RUNX3/CBFA3 Lys186-Tyr415 Accession # Q13761 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | RUNX3, also known as CBFA3 and PEBP2 alpha (polyomavirus enhancer binding protein 2 alpha) is a member of the runt-related (RUNX) family of transcription factors. It is the DNA binding subunit of the heterodimeric transcription factor CBF/PEBP2. RUNX3 is a nuclear effector of the BMP/TGF-beta pathways and its inactivation or reduced expression is associated with numerous human malignancies. Two isoforms that differ in their N-terminal 5/19 residues have been reported. The 415 amino acid residue of human RUNX3 shares 91% amino acid sequence homology with mouse or rat RUNX3. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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